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Generic Viagra

Viagra

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Generic Cialis

Cialis

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Viagra vs Cialis, which is better?

At present, preparations such as Viagra (Sildenafil) by Pfizer Incorporated and Cialis (Tadalafil), fruit of the collaboration between Eli Lilly Pharmaceutical Company and YCOS Incorporated, are widely used for the treatment of erectile dysfunction (ED). The first entered the market in 1996, while the second was launched in 2003.

The action mechanism of both preparations consists in phosphodiesterase type 5 (PDE 5) enzyme inhibition that metabolizes 3`:5`-cyclic guanosine monophosphate (GMP), which is responsible for penis erection. To maintain the necessary GMP level they used a routine method consisting in the inhibition of the enzyme that splits GMP.

The data on the pharmacokinetics of these preparations are in favor of Cialis. Thus, the period of Viagra’s effective half-life is about 3 – 5 h (depending on dosage), while that of Cialis is 17.5 h. Viagra is effective for maintaining an erection for 4 h, while Cialis (20 mg) works for 36 h.

The side effects of Viagra and Cialis are quite similar: vertigo, headaches, diarrhoea, nausea, symptoms of the flu (stuffy nose), hot flashes, backache, stomach ache, and arthralgia.

Although these side effects were transient and benign, or sometimes moderate, the makers of the Cialis preparation noted a decrease of intensity in cases where the drug was taken over a longer period of time. Both preparations are contraindicative in men taking nitro preparations.

While Viagra is the first generation preparation and has been in the market for 5 years, there are some facts against it. In July 2002, Harold Millman, an American toxicologist, published the results of Viagra side effects research in Annals of Pharmacotherapy. The users of the preparation experienced vertigo, disorientation, amnesia. Twenty-two men (out of 270) suspected that Viagra stimulates aggression, 13 that it provokes violence, and 6 people asserted that taking Viagra had given rise to a strong desire to kill someone. These side effects became evident when the maximum dozes of the preparations were taken.

Another source (Illustrated Thesaurus, Sex) pays attention to the incompatibility of Viagra with alcohol. The overdosing of Viagra cost the lives of many pensioners. Among the side effects are neuropsychiatry (high aggression), fatal outcome (more than 1000 cases were registered), and paralysis. Researchers of Cialis noted the absence of restrictions to taking the medicine with food and alcohol, which heightens the ease and meets the patients’ needs in terms of their way of life.

An analysis of the existing facts about the characteristics of Viagra and Cialis allows us to give preference to the latter. Nevertheless, you should not forget that this preparation is new in the pharmaceutical market and the appearance of some additional information about its pharmacological and other features is inevitable. Read more about Viagra vs Cialis

The erectile dysfunction drug Viagra may have found a new, potentially life-saving use in hospital pediatric intensive care units, researchers report.
Australian researchers gave the drug to 15 babies with congenital heart disease who were being weaned from inhaled nitric-oxide therapy, a treatment that ICUs use to help these infants survive.
Viagra Helps COPD Patients Control Pulmonary Blood Pressure
The drug sildenafil, popularly known as Viagra, may help people with chronic obstructive pulmonary disease control the illness-related blood pressure spikes in the heart's pulmonary artery, a new study found.
Could a widely used treatment for depression be a remedy for osteoporosis?
Researchers have discovered that the drug Prozac also increases bone mass, at least in adult mice.
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